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ABC 294640 hydrochloride
CAS No. 1185157-59-8
ABC 294640 hydrochloride( ABC294640 | Opaganib | ABC-294640 )
Catalog No. M10629 CAS No. 1185157-59-8
ABC 294640 (ABC294640, Opaganib)?is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameABC 294640 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionABC 294640 (ABC294640, Opaganib)?is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
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DescriptionABC 294640 (ABC294640, Opaganib)?is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM; shows no activity against SphK-1 with IC50 of >100 uM; attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments; demonstrates antitumor activity in adenocarcinoma xenograft models.Blood Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsABC294640 | Opaganib | ABC-294640
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PathwayImmunology/Inflammation
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TargetSphK
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RecptorSphK
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1185157-59-8
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Formula Weight417.374
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Molecular FormulaC23H26Cl2N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl.Cl
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Chemical Name3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. French KJ, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.
2. Maines LW, et al. Inflammopharmacology. 2010 Apr;18(2):73-85.
3. Beljanski V, et al. J Pharmacol Exp Ther. 2010 May;333(2):454-64.
4. Antoon JW, et al. Endocrinology. 2010 Nov;151(11):5124-35.
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